Mechanism and the Origins of Stereospecificity in Copper Catalyzed Ring Expansion of Vinyl Oxiranes

 

Mechanism and the Origins of Stereospecificity in Copper Catalyzed Ring Expansion of Vinyl Oxiranes: A Traceless Dual Transition Metal-Mediated Process

Abstract : Density functional theory computations of the Cu-catalyzed ring expansion of vinyloxiranes is mediated by a traceless dual Cu(I)-catalyst mechanism. Overall, the reaction involves a monomeric Cu(I)-catalyst, but a single key step, the Cu migration, requires two Cu(I)-catalysts for the transformation. This dual-Cu step is found to be a true two Cu(I)-transition state rather than a mono Cu(I)-transition state in the presence of an adventitious, spectator Cu(I). Both Cu(I) catalysts are involved in the bond forming and breaking process. The single Cu(I) transition state is not a stationary point on the potential energy surface. Interestingly, the reductive elimination is rate-determining for the majordiastereomeric product, while the Cu(I)-migration step is rate-determining for the minor. Thus, while the reaction requires dual Cu(I)-activation to proceed, kinetically, the presence of the dual-Cu(I) step is untraceable. The diastereospecificity of this reaction is controlled by the Cu migration step. Suprafacial migration is favored over antarafacial migration due to the distorted Cu π–allyl in the latter.

Mustard, T. J. L.; Mack D. J.; Njardarson, J. T.; Cheong P. H.-Y. J. Am. Chem. Soc. [Just Accepted], DOI:10.1021/ja310065z. Published online: December 31, 2012